N1-methyl-pseudouridine

Now available: Oligonucleotides with N1-methyl-pseudouridine.
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New: Reactive modifiers

Reactive dyes and modifiers for postynthetic labeling of oligonucleotides: azide, alkyne, succinimidyl ester modifiers.
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Probes with BMN Quenchers

BMN-Q535, BMN-Q1 , BMN-Q2 and BMN-Q620 as efficient alternatives to conventional dark quenchers (BHQ, BBQ, TQ) in qPCR probes [Read more]

VIC Dye

Primer and probes with
5'-modification 2’-chloro-7’-phenyl-1,4-dichloro-6-carboxyfluorescein (VIC)
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Electrochemical Detection

Redox modifications: Nile Blue, Methylene Blue, Ferrocene, Antraquinone
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biomers.net and COVID-19
biomers.net is operating at normal capacity.

Our phone support times are currently from 8 am to 5 pm until further notice. You certainly can also contact us via email any time.

qPCR primer und probes for your COVID-19 research:
We produce primers and probes for SARS-CoV2 qPCR assays as recommended by WHO. These oligonucleotides are available with all established dye/quencher combinations and also as large scale syntheses (XL and XXL scale). Please contact our customer support team for futher information.
Modifications for enzymatic coupling of oligonucleotides to proteins
HaloTag®

Benzylguanine und Benzylcytosine

Triglycin (Gly-Gly-Gly) for sortase-mediated linking reaction
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5'-Hydrazide Modification: Reactive Linker
An efficient way to link oligos to other biomolecules is the hydrazide-aldehyde coupling. Aldehydes represent highly reacted carbonyl compounds that can react with hydrazides under neutral or slightly acidic conditions to form stable hydrazone conjugates in a fast and efficient way. Thus, a conjugation of oligonucleotides to other (bio)molecules can be achieved easily under physiological conditions.


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Lipophilic modifications
Lipophilic modifications on oligos play an important role in drug delivery and nanobiotechnology.

Cholesterol
Conjugates with palmitic-, stearic-, elaidic-, oleic acid
Distearoyl-Lipid
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamin (DOPE) conjugate
Tocopherol (Vitamine E), Trolox, Folic acid conjugate
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DNA oligos
- Unmodified oligos
- short and extra long oligos
- XXL DNA (10-500 mg)
- Sequence modifications
- Wobbles
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RNA oligos
- unmodified RNA
up to 120 bases
- RNA oligo annealing
- XL and XXL RNA (5-50 mg)
- RNA modifications
- 2´-modified RNA
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PNA oligos
- Peptide nucleic acid oligomers (PNA)
- 6-25 bases
- various modifications possible
- extreme stability
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qPCR Probes
- Dual-Labelled Oligos
- Double Quenched Probes
- MGB Probes
- Molecular Beacons
- Scorpions
- FRET Probes
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FISH Probes
- Fluorescence probes
mono-, dope-, tetraProbes
- multiProbes
- HRP probes
- smiFISH Oligo Pools
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Literature Highlight
- Rapid SARS-CoV-2 detection with RT-RPA and RT-LAMP
- Gly-Gly-Gly-modified oligonucleotides
- L-DNA oligonucleotides for DNA-PAINT
[Read more]