An efficient way to link oligos to other biomolecules is the hydrazide-aldehyde coupling. Aldehydes represent highly reacted carbonyl compounds that can react with hydrazides under neutral or slightly acidic conditions to form stable hydrazone conjugates in a fast and efficient way. Thus, a conjugation of oligonucleotides to other (bio)molecules can be achieved easily under physiological conditions.


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Take advantage of state-of-the-art synthesis technology:
Oligonucleotides with all popular modifications at reasonable prices and with a reliable quality. Oligos for PCR, short, unmodified and quickly delivered are offered as well as high quality RNA oligos, probes for qPCR and FISH or reliable cloning oligos of (nearly) any length.
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Protein tags such as SNAP or CLIP tag as well as HaloTag® but also the sortase-mediated linking reaction are used in various applications:

- detection
- localisation
- protein-protein interactions
- labelling, multiplex labelling (e.g. SNAP / CLIP tag)
- enzymatic coupling of different proteins or other biomolecules

Oligonucleotide-based biosensors (E-sensors) for
electrochemical detection can be labelled with
- NEW: Nile Blue
- Methylene blue
- Ferrocene
- Anthraquinone
- Viologen
- Atto MB2

Carbohydrate oligo conjugates play an important role in improving uptake and cell availability of siRNA and antisense oligonucleotides.

Various carbohydrates (sugars) are available for oligo coupling:
- N-Acetylgalactosamine (GalNAc)
- ß-Cyclodextrin
- Glucopyranose

smiFISH - single molecule inexpensive fluorescence in situ hybridisation

A set consisting of short, target-binding, unlabelled oligo probes (OligoPool) and a double-labelled secondary probe allows extremely sensitive and specific in situ RNA detection.



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Protocols, interesting literature and further information around the topic of oligonucleotides.

- Smart-Seq for transkriptome analysis (Picelli et al., 2014)
- Mediator Probe PCR (Faltin et al., 2012)
- MiL-FISH: Multi-labelled oligonucleotides (Schimak et al., 2015)