Carbohydrate oligonucleotide conjugates
 

Carbohydrate-oligonucleotide conjugates have become increasingly important in recent years, particularly with regard to an increased uptake and cell availability of siRNA and antisense oligonucleotides. Of particular interest here is N-acetylgalactosamine (GalNAc), which can bind to the asialoglycoprotein receptor (ASGPR) in hepatocytes.

The following picture shows some examples of the attachment of carbohydrates (sugars) to oligonucleotides via different linker structures:

• N-Acetyl-Galactosamin (GalNAc)
• ß-Cyclodextrin
• Glucopyranose

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