L-RNA
 

By nature, only one stereoisomer of ribose is used. In double stranded nucleic acids, the D-form of ribose naturally forms a right-handed helix. Compared to naturally occurring aptamers, the corresponding chemically synthesised enantiomer differs only by its specific sugar residue, the L-ribose. In comparison to their D-form, double-stranded molecules of these nucleic acids form a left-handed helix and show extreme stability against degradation by nucleases.

Now available: biomers.net offers the synthesis of L-RNA oligonucleotides.
For ordering dye modifications or D-RNA/L-RNA chimeras, please contact our customer support team.

Literature: 
1. Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer. Helmling S, Maasch C, Eulberg D, Buchner K, Schröder W, Lange C, Vonhoff S, Wlotzka B, Tschöp MH, Rosewicz S, Klussmann S; PNAS (2004), Vol. 101, No. 36, 13174–13179.

2. Spiegelzymes: Sequence Specific Hydrolysis of L-RNA with Mirror Image Hammerhead Ribozymes and DNAzymes. Wyszko E, Szymanski M, Zeichhardt H, Müller F, Barciszewski J, Erdmann VA; Plos One (2013), Vol. 8, Issue 1.