By nature, only one stereoisomer of ribose is used. In double stranded nucleic acids, the D-form of ribose naturally forms a right-handed helix. Compared to naturally occurring aptamers, the corresponding chemically synthesised enantiomer differs only by its specific sugar residue, the L-ribose. In comparison to their D-form, double-stranded molecules of these nucleic acids form a left-handed helix and show extreme stability against degradation by nucleases.
Now available: biomers.net offers the synthesis of L-RNA oligonucleotides.
For ordering dye modifications or D-RNA/L-RNA chimeras, please contact our customer support team.
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2. Spiegelzymes: Sequence Specific Hydrolysis of L-RNA with Mirror Image Hammerhead Ribozymes and DNAzymes. Wyszko E, Szymanski M, Zeichhardt H, Müller F, Barciszewski J, Erdmann VA; Plos One (2013), Vol. 8, Issue 1.